1/3. Pleomorphic giant cell carcinoma of the prostate.We report the clinical and pathologic features of 2 cases of pleomorphic giant cell carcinoma of the prostate. One case was found at autopsy in a 77-year-old man and was composed of high-grade prostatic adenocarcinoma with prominent anaplastic giant cells. The patient presented with metastases to multiple retroperitoneal lymph nodes, liver, and lumbar vertebrae. The second case occurred in a 45-year-old man who underwent transurethral resection of the prostate and was found to have high-grade prostatic adenocarcinoma with an extensive anaplastic giant cell component. The patient presented with distant metastases and died within 9 months. Both regular adenocarcinoma and anaplastic giant tumor cells displayed cytoplasmic immunoreactivity for prostate-specific antigen, prostatic acid phosphatase, and keratin AE1/AE3; in one case, scattered cells were also positive for chromogranin and epithelial membrane antigen. Pleomorphic giant cell carcinoma is a rare variant of prostatic adenocarcinoma with a poor prognosis that should be considered in the differential diagnosis of prostatic pleomorphic tumors.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |
2/3. Follicular dendritic cell sarcoma mimicking giant cell carcinoma of the pancreas.Extranodal follicular dendritic cell (FDC) tumors are rare. Recognition of the morphological spectrum of FDC tumors is important to clinical diagnosis. Herein is presented a case of pancreatic FDC sarcoma with unusual clinicopathological features. A 64-year-old male patient presented with weight loss, poor appetite, abdominal fullness, mild anemia and mild peripheral eosinophilia. Histologically, the tumor was composed of both epithelioid and spindle cells with abundant intracytoplasmic hyaline globules. These tumor cells were positive for CD21, CD23, CD35, S-100 protein, fascin and clusterin. Both epithelioid and spindle tumor cells independently colonized the liver and formed two tumor nodules 18 months after the initial resection. Notably, the two hepatic metastases additionally acquired patchy expression of human leukocyte antigen-DR. The epithelioid FDC in one of the hepatic lesions transformed into numerous bizarre giant cells, which could easily be confused with a metastatic giant cell carcinoma from the pancreas. FDC tumor should therefore be included in the differential diagnoses when dealing with a giant cell tumor.- - - - - - - - - - ranking = 0.5keywords = antigen (Clic here for more details about this article) |
3/3. "Osteoclastic" giant cell carcinoma of the pancreas. Report of a case with aspiration cytology.BACKGROUND: Osteoclastic giant cell carcinoma (OGC) is an uncommon variant of ductal carcinoma of the pancreas. It is important to differentiate this variant from other giant cell pancreatic lesions, particularly the more aggressive pleomorphic giant cell carcinoma. CASE: Aspiration cytology was performed in a case of OGC. Aspirates of OGC demonstrated three populations of discohesive cells: (1) large, bizarre, pleomorphic malignant giant cells with high nuclear/cytoplasmic ratios, irregular nuclear membranes and coarse chromatin; (2) spindle or small mononucleate cells; and (3) bland, osteoclastlike epithelial giant cells with multiple small, round, central nuclei and prominent nucleoli. CONCLUSION: Multinucleate giant cells can be seen in pancreatic abscesses, fat necrosis, pseudocysts, tuberculosis, sarcoidosis and fungal infections. When the cells are associated with malignant epithelial cells, the differential diagnosis includes metastatic carcinoma, malignant melanoma, Hodgkin's disease, large cel anaplastic lymphoma, trophoblastic tumor, epithelioid sarcoma, malignant fibrous histiocytoma, angiosarcoma and rhabdomyosarcoma. Immunohistochemical stains, such as vimentin, S-100, leukocyte common antigen, human chorionic gonadotropin, factor vii Ag, actin and desmin play an important role in differentiating between these lesions.- - - - - - - - - - ranking = 0.5keywords = antigen (Clic here for more details about this article) |