1/2. Microcystic adnexal carcinoma arising in the setting of previous radiation therapy.While there are several reports of microcystic adnexal carcinoma developing in patients within sites of previous therapeutic irradiation, this relationship is not well described in the dermatologic literature. We report a case of a 42-year-old man with a remote history of therapeutic irradiation following surgical resection of periorbital rhabdomyosarcoma. Subsequently, he developed multiple basal cell carcinomas and a microcystic adnexal carcinoma within the field of irradiation. The histologic features were those of a classic microcystic adnexal carcinoma, with well differentiated nests and cords of keratinocytes displaying follicular and ductular differentiation infiltrating diffusely into the reticular dermis. Dense fibrosis was present surrounding the neoplastic keratinocytes. Nuclear atypia and mitotic figures were not identified. A carcinoembryonic antigen (CEA) stain demonstrated glandular differentiation. It is important for dermatologists to be aware of the apparent relationship between the rare microcystic adnexal carcinoma with its innocuous scar-like clinical appearance and prior local radiation therapy.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |
2/2. bowen's disease with invasive adnexal carcinoma: the pluripotential nature of bowen's disease cells.bowen's disease rarely exhibits multiple combinations of premalignant and/or malignant skin lesions. bowen's disease with invasive adnexal carcinoma was originally described by Kao, but is not well recognized by clinicians due to its rarity and lack of specific clinical features of this condition. Herein, we describe three unusual cases of bowen's disease with invasive adnexal carcinoma. The two distinct neoplastic areas exhibited continuity both clinically and histologically. The plaque lesions possessed clinical features typical of bowen's disease. In cases 1 and 3, we confirmed the adnexal tumor within tumors of bowen's disease, the diagnosis of which is eccrine porocarcinoma. The tumor in case 2 was characteristic to trichilemmal carcinoma. Immunohistochemically, the tumor cells of bowen's disease and the adnexal carcinoma differed in antigenicities. The present cases support a notion that bowen's disease maintains a pluripotential nature.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |