1/8. Primary intracranial Burkitt's lymphoma in an infant.A case of intracranial Burkitt's lymphoma is reported in a child whose symptoms began at 3 months of age with a definite histologic diagnosis established at 18 months. Serologic studies demonstrated high antibody titers to Epstein-Barr virus (EBV) in the patient and in four out of five members of the immediate family. The patient also demonstrated immunity to antigens derived from African Burkitt's lymphoma cell lines. The autopsy findings strongly support the case for the primary intracranial origin of the neoplasm and a perinatal infection with EBV is probable in this case.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |
2/8. Fine specificities of antibodies in sera and cerebrospinal fluid in herpes virus infections of the central nervous system as detected by the antigen variable immunoblot technique.Applying the immunoblot technique a sensitive and specific method was developed for the detection of intrathecally synthesized antibodies against individual specific proteins that are antigens of various infectious agents causing encephalitis. Paired serum and cerebrospinal fluid (CSF) samples from five patients with herpes virus infections of the central nervous system (CNS) (three herpes simplex virus encephalitis, one varicella zoster virus encephalitis, one zoster ganglionitis) were investigated for the presence of locally produced IgG against the electrophoretically separated antigens of herpes simplex virus (HSV), varicella zoster virus (VZV) and human cytomegalovirus (HCMV), as well as for IgM antibodies in one case of HSV encephalitis. In two cases (HSV encephalitis and VZV encephalitis) four and one antibody, respectively, were found that were synthesized intrathecally only. In the other cases the patterns of sera and CSF antibodies were similar, the CSF antibodies showing an all-over stronger reaction, at identical IgG concentrations. In contrast to the conception of a 'limited heterogeneity' of intrathecal antibody synthesis in encephalitis, we thus found an 'expanded heterogeneity' of the intrathecally synthesized antibodies in comparison to the corresponding serum antibodies.- - - - - - - - - - ranking = 6keywords = antigen (Clic here for more details about this article) |
3/8. diagnosis of CNS lymphoma using immunofluorescent phenotyping of CSF mononuclear cells.We describe the use of a panel of monoclonal antibodies, directed against leukocyte surface antigens to characterize CSF mononuclear cells with regard to malignancy when cytopathology was inconclusive. Cytocentrifuged preparations from three patients in which traditional modalities had not yielded a diagnosis were studied, utilizing a panel of antibodies for B and T cell antigens. All three patients were found to have B cell lymphoma of the CNS. Rapid institution of the appropriate therapy resulted in marked improvement of CNS symptoms in each case. Our results indicate that in patients with CNS disease and CSF pleocytosis of undefined nature, this technique may provide rapid and precise diagnostic information.- - - - - - - - - - ranking = 2keywords = antigen (Clic here for more details about this article) |
4/8. Epidemic hemorrhagic fever in Hubei Province, The People's Republic of china: a clinical and serological study.Between July 1975 and April 1980, 71 patients were admitted to the Second Attached Hospital of Hubei Provincial Medical College in Wuchang with the diagnosis of epidemic hemorrhagic fever (EHF). The clinical course among these patients was similar to that described for patients with Korean hemorrhagic fever, and hemorrhagic fever with renal syndrome of the U.S.S.R. The overall mortality was 11.2 percent. Sera obtained from some of these patients as well as from patients admitted to the First Attached Hospital of Hubei Provincial Medical College were tested against an antigen associated with Korean hemorrhagic fever and showed exceedingly high antibody titers. We conclude that EHF in Central china represents the same or a closely related disease process as Korean hemorrhagic fever.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |
5/8. Demyelinating neuropathy and monoclonal IgM antibody to myelin-associated glycoprotein.We studied a patient with demyelinating neuropathy and monoclonal IgM kappa antibody to the major myelin-associated glycoprotein (MAG). Binding of this monoclonal antibody to the myelin antigen was demonstrated by immunoelectroblot. Binding to MAG seemed to be specific, because it was completely inhibited by MAG isolated from human myelin. Immunostaining was observed with MAG from CNS and peripheral nervous system myelin.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |
6/8. Neurologic complications of primary sjogren's syndrome.Although peripheral nervous system disease has been well documented in Sjogren's syndrome (SS), central nervous system (CNS) involvement is considered distinctly uncommon. Sixteen patients with primary SS and CNS disorders not attributable to other causes were the subjects of this study. Cerebral manifestations, both focal and diffuse, as well as spinal cord disease, were observed. Peripheral vasculitis occurred in 12 patients (75%), 83% of whom had anti-Ro(SSA) antibodies. The high proportion of patients with concomitant peripheral vasculitis, and the observed association with antibodies to the Ro(SSA) antigen system which, in other studies, has been linked to vasculitis in SS, suggest that an immune vasculopathy may play a role in the pathogenesis of the CNS disease of SS.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |
7/8. diagnosis of cytomegalovirus infections of the nervous system by immunocytochemical demonstration of infected cells in cerebrospinal fluid.OBJECTIVES: Infections caused by the cytomegalovirus (CMV) are frequent complications in patients with the acquired immunodeficiency syndrome. diagnosis of CMV infections of the nervous system is still difficult. methods: We evaluated immunocytochemical staining for a CMV early antigen in cells prepared from the cerebrospinal fluid of patients with clinical evidence for neural CMV infections and from controls. RESULTS: CMV positive cells were found in four samples of patients with clinical evidence of CMV infection. Three of these patients were suffering from myeloradicalitis, one had a severe brain stem encephalitis. No CMV positive were found in controls. CONCLUSIONS: Immunocytochemical staining of CSF cells may be helpful in the diagnosis of CMV infection of the central nervous system and of the nerve roots.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |
8/8. Disseminated BK type polyomavirus infection in an AIDS patient associated with central nervous system disease.A 27-year-old man with hemophilia type A and acquired immunodeficiency syndrome developed a subacute meningoencephalitis, associated with a normotensive internal hydrocephalus, 14 weeks before his death. From cerebrospinal fluid and brain autopsy material, a virus could be isolated and was classified by Southern blot analysis and restriction endonuclease reactions as the human polyomavirus BK. The postmortem findings of polyomavirus antigen and bk virus dna in various cell types of the kidneys, lungs, and central nervous system strongly suggest that BK virus was the causative agent of a tubulointerstitial nephropathy, an interstitial desquamative pneumonitis, and a subacute meningoencephalitis with accentuation of the ventricular and meningeal surfaces of the brain. Besides distinctive cytopathic effects, the presence of intranuclear inclusions was a prominent histopathological feature. Therefore, the human polyomavirus BK should be regarded as a new candidate on the still growing list of opportunistic pathogens in acquired immunodeficiency syndrome.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |