1/13. Tubulovillous adenoma of the urinary bladder.We report a case of vesical tubulovillous adenoma that occurred in a background of protracted chronic cystitis with intestinal-type glandular metaplasia and extensive cellular atypia (dysplasia) in the flat mucosa. flow cytometry analysis showed dna aneuploidy in the adenoma. Increased expression of the tumor suppresser gene, p53, and also of cellular proliferation markers (proliferating cell nuclear antigen and MIB-1) were detected in the villous adenoma and in the dysplastic regions of the flat metaplastic mucosa. These findings provide insight into the biology of intestinal metaplasia and also lend support to the theory of the chronic irritation-metaplasia-dysplasia-carcinoma sequence.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |
2/13. urinary tract infection due to a mucoid (M) form of salmonella. A "new" transformation from M form into T1 form.An eighty-year-old patient suffering from prostatic hypertrophy developed cystitis associated with fever, macrohematuria and significant bacteriuria. In urine cultures, growth of a mucoid (M) form of salmonella was seen which changed into a T1 form after having been stored at room temperature or passed through U tubes. While the M form did not agglutinate in salmonella O and H antisera, H antigens of the T1 form could be identified as l,v and 1.7. The isolate was therefore designated S.I M T1:l,v:1.7. To date, no such M-T1 variation has been described. For diagnostic and epidemiologic purposes salmonella M forms should be transformed into the N form or a T form (as in our case), because it is possible to demonstrate O or T and H antigens in these forms. The method of transformation and the pathogenesis of urinary excretion of salmonellae are briefly described.- - - - - - - - - - ranking = 2keywords = antigen (Clic here for more details about this article) |
3/13. Adenovirus hemorrhagic cystitis in a stem cell transplant patient: the first reported case in Southeast Asia.Adenovirus (AdV) infections are prevalent in bone marrow transplant patients, usually associated with significant morbidity and mortality. Hemorrhagic cystitis (HC) is a major complication mainly attributed to this virus. The authors report a case of AdV HC in a myelodysplastic patient undergoing peripheral blood stem cell transplantation. The diagnosis was confirmed by positive urine AdV antigen using indirect immunofluorescence assay. The patient gradually improved after adequate hydration, supportive treatment and reduced dose of cyclosporine, and was discharged on the ninth day of hospitalization. To the authors' knowledge, this is the first case of AdV HC in stem cell transplantation in Southeast Asia.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |
4/13. Renal transplant patient with polyoma virus bladder infection and subsequent polyoma virus nephropathy.Polyoma virus nephropathy (PVN) is a significant cause of renal allograft dysfunction in transplant patients. A 58-year-old male received a cadaveric renal transplant and 12 weeks later presented with fever, diarrhea, and dysuria. He was diagnosed with a polyoma virus infection of the bladder by a transurethral bladder biopsy. One year post-transplant, he presented with renal allograft dysfunction and was diagnosed by biopsy with PVN of the non-native kidney. The diagnosis of a polyoma virus infection was confirmed by immunoreactivity to the polyoma T-antigen. We suggest that polyoma virus infection of the bladder be included in the differential diagnosis of urinary dysfunction in post-transplant patients, as such infections might be an under-recognized comorbidity in individuals with PVN.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |
5/13. agranulocytosis and anaemia induced by sulfametopyrazine in a sulfametopyrazine-trimethoprim combination.We report a case of prolonged fever, agranulocytosis, and anaemia associated with the long acting sulphametopyrazine-trimethoprim combination (Kelfiprim). A woman of 23 years took an overdose of 13 tablets over five days for presumed cystitis. One day after the last dose the patient developed fever and a generalised rash. The fever persisted and her previously normal leukocyte count decreased to 1.8 x 10(9)/1. After treatment with paracetamol the fever settled briefly, and then recurred for another 16 days. A later peripheral blood leukocyte count of 0.77 x 10(9)/1, haemoglobin of 10.8 g/dl, and a hypocellular bone marrow with depressed granulopoiesis and haemopoiesis suggested marrow suppression induced by sulfametopyrazine. Since the IgM antibody against the Epstein-Barr virus capsid antigen was detected, the adverse drug reaction might have been aggravated by this virus. The case highlights the risk of severe haematological adverse reactions associated with sulphonamide treatment, and argues for the use of trimethoprim alone for uncomplicated cystitis.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |
6/13. A rare case of mucous-secreting villous adenoma of the bladder.A case of mucous-secreting villous adenoma of the urinary bladder associated with cystitis glandularis is reported which led to radical cystectomy because of the extensive bladder involvement. An immunohistochemical study was performed in order to detect ABH tissue antigens. The histogenesis and the possible malignant potential of this neoplasm are discussed.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |
7/13. Eosinophilic food-induced cystitis.In this work we study a case of eosinophilic cystitis induced by the ingestion of some specific foodstuffs (tomatoes, coffee, carrots) and strong smells (petrol) in a female patient with clinical history of extrinsic permanent rhinitis and Quincke's oedema. skin tests and RAST showed specific antibodies against Dermatophagoides Pteronyssimus, Farinae, alternaria and cladosporium. These antigens were related to the rhinosinusitis and facial oedema. Provocative tests were used to make the definitive diagnosis. They were carried out when the patient was symptomless and the following parameters were taken into account: the time elapsed estil the appearance of the symptoms, the intensity of urinary symptoms, polakiuria, urgency and prepubic pain, cystoscopy, bladder histology, urine volume and pre-and post-test histaminuria in 24 hours. Bladder histology subsequent to the intake of tomato showed capillary congestion and severe inflammatory infiltration with a clear predominance of eosinophils. The histaminuria values after the ingestion of tomatoes, carrots and coffee were superior to basal determinations, amounting to a maximum of 1229 mcg./l. in 24 hours. The allergic origin of these eosinophilic cystitis is proved by the appearance of urologic symptoms and eosinophilic infiltration of the bladder subsequent to provocative tests, which subside when the antigens which bring them about are removed.- - - - - - - - - - ranking = 2keywords = antigen (Clic here for more details about this article) |
8/13. urinary tract infection as a cause of lichen planus: metronidazole therapy.A 51-year-old woman with generalized lichen planus for 23 years experienced total involution of her lesions during metronidazole therapy. Discontinuance of the treatment on two occasions led to partial recurrence of the skin lesions, which again promptly cleared on reinstitution of metronidazole. It is believed that this patient's lichen planus was an immune reaction to circulating bacterial antigen. The presumed source was a chronic urinary bladder infection. Continued remission of the lichen planus and the cystitis was subsequently achieved for over a year by daily prophylactic nitrofurantoin therapy. Identification and eradication of chronic foci of infection are suggested for the management of generalized chronic lichen planus.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |
9/13. Villous adenoma of the urinary bladder: a morphologic or biologic entity?Villous adenomas in the urinary bladder are rare neoplasms whose malignant potential is unclear. A case of a morphologically benign non-invasive mucin producing papillary neoplasm of the urinary bladder associated with cystitis glandularis is presented. Absence of A tissue isoantigen from the neoplastic and metaplastic cells and the presence of H tissue isoantigen in both neoplastic and metaplastic cells is observed in a patient whose blood type is A, indicating incomplete maturation of surface coat constituents. The histologically benign appearance of this lesion may belie a malignant potential.- - - - - - - - - - ranking = 2keywords = antigen (Clic here for more details about this article) |
10/13. Eosinophilic cystitis: an uncommon form of cystitis.Since 1959, 39 cases of eosinophilic cystitis have been reported in the literature. Eosinophilic cystitis is a rare form of allergic cystitis in patients who usually have a strong allergic history. It mimics other forms of intractable cystitis, such as interstitial cystitis, tuberculosis and bladder neoplasms. It is caused by various antigens that form immune complexes at the bladder level and stimulate eosinophilic infiltration. food allergens, medications, topical agents and parasites have been implicated. The diagnosis is made by excluding all other forms of cystitis.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |
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