1/5. adult herpetic laryngitis with concurrent candidal infection: a case report and literature review.Rarely, adult herpetic laryngitis without involvement of the oropharynx has been reported. However, to our knowledge, laryngitis caused by herpes simplex virus with coexisting candida albicans has not been reported. We report what we believe to be the first case of localized herpetic laryngitis superimposed by laryngeal Candida species infection in an immunosuppressed patient. This diagnosis was made on the basis of the findings of a laryngeal mucosal biopsy and ancillary testing using fungal stains and immunohistochemical stains for herpetic antigens. We also review the literature and discuss the clinical and diagnostic presentations, including potential pitfalls in the diagnosis.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |
2/5. Fatal pulmonary transfusion reaction to plasma containing donor HLA antibody.A 55-year-old woman with common variable immunodeficiency and mild chronic obstructive lung disease received 3 units of plasma as immunoglobulin replacement therapy. During the administration of the final unit, her temperature rose 1 degree C, with no other observable symptoms. Fifteen minutes later she developed shortness of breath without nausea, vomiting, rash, or pruritus. In 30 min she lost consciousness, was breathless, and cyanotic. Resuscitative efforts failed. autopsy failed to pinpoint a cause of death. There was no evidence of ABO or Rh incompatibility, bacterial contamination, or hemolysis. There were no neutrophil, platelet or IgA antibodies detectable in the patient or the 3 plasma donors. There were no lymphocytotoxic HLA antibodies in the patient or two of the plasma donors. The third donor had HLA-B35 lymphocytotoxic antibodies that did not agglutinate or aggregate neutrophils. The patient's HLA type was A2, A3; B35, B40. Lymphocytotoxic crossmatches using lymphocytes of the patient were positive with plasma from the third donor but negative with the other two. An eluate prepared from post-mortem lung parenchymal tissue was cytotoxic to 7 of 8 panel lymphocytes positive for the hla-b35 antigen but not with cells lacking B35. The implicated plasma donor was healthy with a history of 6 pregnancies. This case report illustrates the potential hazard of transfusion of plasma containing HLA antibodies.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |
3/5. Chronic airflow obstruction in a patient with pigeon breeder's lung: prevalence of IgE antibodies to avian antigens.We report a case of pigeon breeder's lung in which chronic airflow obstruction and not restrictive lung disease was predominant. The patient's disease was severe enough to require hospitalizations twice to reverse respiratory failure. helium-oxygen flow volume curves were consistent with a peripheral site of flow limitation, and immunoserological studies disclosed specific IgE as well as precipitating antibody responses to pigeon antigens. Immunological studies on 18 other patients with pigeon breeder's lung demonstrated a prevalence rate of specific IgE antibodies of 78%, a frequency not previously recognized. Exposures to avian antigens must be considered in patients with obstructive lung disease of unknown etiology.- - - - - - - - - - ranking = 6keywords = antigen (Clic here for more details about this article) |
4/5. bronchopneumonia caused by propionibacterium acnes.propionibacterium acnes was identified as the pathogen in a case of subacute lung infection by examination of an open lung biopsy specimen. The patient was a 65-year-old male with exacerbation of chronic lung disease. The organism was isolated in pure culture and was present in large numbers on Gram stain. Histological examination demonstrated active interstitial fibrosis; macrophages laden with propionibacterium acnes antigen were revealed using a peroxidase-antiperoxidase stain. This is the first report of subacute infection of pulmonary tissue due to this organism.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |
5/5. Aberrant histoplasma capsulatum. Confirmation of identity by a chemiluminescence-labeled DNA probe.A cottony, light tan, filamentous fungus with pear-shaped microconidia and lacking tuberculated macroconidia was isolated from a bronchial lavage specimen. Subculture on several media at 37 degrees C failed to convert the fungus to a yeast form after several weeks; attempts at in vivo conversion in mice were also unsuccessful. Sera obtained several months apart showed M bands with histoplasma capsulatum (HC) antigen by immunodiffusion and an increase in complement fixation titers with mycelial and yeast phase antigens of HC. Parallel identity was obtained on two occasions with exoantigen culture confirmation reagents for HC from Immuno-Mycologics as well as one of identity with Nolan reagents. Extracts from four chrysosporium spp. strains had no identity reactions with HC with either kit. The fungus was identified as HC by the Accuprobe histoplasma chemiluminescence-labeled DNA probe directed at ribosomal rna, whereas all four chrysosporium spp. isolates tested negative. dna probes are a fast and accurate method to confirm the identity of aberrant fungal isolates.- - - - - - - - - - ranking = 3keywords = antigen (Clic here for more details about this article) |