1/14. mycobacterium avium infection of the skin associated with lichen scrofulosorum: report of three cases.We report three Japanese children with mycobacterium avium infection of the skin who also developed lichen scrofulosorum, a previously undescribed association. They were healthy except for the presence of several noduloulcerative lesions associated with multiple asymptomatic papules on the trunk and extremities. histology of the ulcerative lesions showed features of mixed-cell granuloma, whereas the papular lesions showed features consistent with lichen scrofulosorum. M. avium was identified by polymerase chain reaction-aided dna-dna hybridization analysis in specimens obtained from the noduloulcerative lesions. Both the noduloulcerative and the papular lesions responded well to combination chemotherapy consisting of antituberculous agents and antibiotics.- - - - - - - - - - ranking = 1keywords = health (Clic here for more details about this article) |
2/14. Cutaneous tuberculosis.Tuberculosis continues to be a significant health problem in developing countries. Although cutaneous tuberculosis is uncommon, disseminating skin involvement may still be seen, especially patients from rural areas. A case is reported of disseminated tuberculosis presenting with different clinical forms of cutaneous lesions, pulmonary and liver involvement in an immunocompetent patient.- - - - - - - - - - ranking = 1keywords = health (Clic here for more details about this article) |
3/14. Unusual presentation of mandibular extraoral sinus in a fourteen year old girl: a case report.A case of fourteen year old healthy girl with complaint of a discharging sinus on the lower right side of face is reported. All teeth were vital and there was no evidence of periodontitis. There was no history of extraction of a tooth. Total leucocyte count, differential leucocyte count, fasting blood sugar, chest x-ray and routine urine examination were within normal limits. actinomycosis and scrofuloderma which simulate such a condition were ruled out by culture study. The intraoral periapical x-ray of mandibular molar showed questionable periapical changes at the time of presentation. But definite osteolysis was observed in the repeat radiograph after three months. It was decided to extract the second molar and curette the sinus tract. The extraction proved to be difficult. On examination of the extracted tooth, it was found that the mandibular second molar and second premolar were fused together. The radiograph of the tooth taken after extraction showed confluence of the premolar pulp with the periodontal membrane. On follow up, the lesion was found to heal satisfactorily.- - - - - - - - - - ranking = 1keywords = health (Clic here for more details about this article) |
4/14. An unusual case of tissue breakdown secondary to TB.Despite the many advances in technology, research and educational initiatives in tissue viability, wound management remains a complex and challenging area for healthcare professionals. This article describes the management of an unusual groin wound that developed as a result of tissue breakdown secondary to tuberculosis.- - - - - - - - - - ranking = 1keywords = health (Clic here for more details about this article) |
5/14. Perianal ulceration in a "healthy" Chinese man with disseminated tuberculosis.Orificial tuberculosis (OTB) is a rare form of cutaneous mycobacterium tuberculosis infection affecting the mucosa and skin around orifices in patients with advanced internal tuberculosis and poor general health. We report a 72-year-old Chinese man who had a 10-year history of OTB with disseminated tuberculosis infection of the lungs and urinary tract. He appeared surprisingly healthy and had been free from systemic symptoms all along despite widespread tuberculosis. The diagnosis of OTB was established by the microscopic presence of acid-fast bacilli (AFB) in the tissue section and was rapidly confirmed by polymerase chain reaction (PCR) to be mycobacterium tuberculosis. PCR shortens the time of diagnosing rare presentations of cutaneous tuberculosis and prevents delays in treatment. Conventional culture is still important in confirming the diagnosis and screening for drug resistance.- - - - - - - - - - ranking = 6keywords = health (Clic here for more details about this article) |
6/14. A report of cutaneous tuberculosis in siblings.Cutaneous tuberculosis is rarely seen in the united states, and we are unaware of any reports of siblings sharing the diagnosis. We report an instance of cutaneous tuberculosis affecting two sisters. The first sibling had skin biopsy specimen findings suggestive of an infectious source, but special stains and cultures were negative. Only with further evaluation using polymerase chain reaction (PCR) was the diagnosis established. The second sibling had positive staining for acid-fast bacilli, though her cultures were also negative. A high level of suspicion for tuberculosis should be maintained in otherwise healthy children with nonspecific, granulomatous disorders of the skin. PCR may be a useful tool for selected cases in which a high level of clinical suspicion exists, but special stains and cultures are negative.- - - - - - - - - - ranking = 1keywords = health (Clic here for more details about this article) |
7/14. Multiplex PCR-identified cutaneous tuberculosis evoked by mycobacterium bovis BCG vaccination in a healthy baby.This is the first identified case of mycobacterium bovis bacillus Calmette-Guerin (BCG)-derived cutaneous tuberculosis that localizes at a place different from the vaccination site in hosts without immune deficiency. A healthy baby with a developing abscess is described. A multiplex PCR identified the abscess as originating from M. bovis BCG tokyo 172.- - - - - - - - - - ranking = 5keywords = health (Clic here for more details about this article) |
8/14. Metastatic tuberculous abscesses in an immunocompetent patient.The decreased incidence of infectious diseases in developed countries may make their diagnosis difficult. Cutaneous tuberculosis is an example of this fact. A 44-year-old man presented with two painful abscesses on his lower extremities, which developed into chronic ulcers. A cutaneous biopsy revealed necrotizing granulomas in the dermis. Ziehl-Neelsen and periodic acid-Schiff stain were negative. Mantoux test was positive. Tc-99m scintigraphy showed increased uptake in the bone tissue of the left ankle and right tibiae, without direct relation to cutaneous lesions. Chest X-ray showed micronodular, apical, bilateral infiltrates, reduced volume of the right lung, and cavitation of the right superior lobe. mycobacterium tuberculosis was grown from sputum and skin biopsy samples. isoniazid, rifampin and pyrazinamide treatment for 2 months, followed by isoniazid and rifampin for 12 months, resulted in complete resolution. The clinical features of cutaneous tuberculosis in our patient were characteristic of tuberculous abscesses. Some uncommon findings, such as the low number of lesions, negative acid-fast resistant stains in cutaneous biopsy samples and his preserved general state of health, may be explained by a higher competence of the immune system than is usual in this clinical subset of disseminated tuberculosis. Cutaneous tuberculosis should be included in the differential diagnosis of cutaneous abscesses in immunocompetent patients.- - - - - - - - - - ranking = 1keywords = health (Clic here for more details about this article) |
9/14. Multifocal scrofuloderma with disseminated tuberculosis in a severely malnourished child.Tuberculosis and malnutrition continue to be significant health problems in developing countries. Moderate to severe malnutrition can cause immunosuppression and predispose children to various infections. We report disseminated tuberculosis in a severely malnourished Indian child who presented primarily with cutaneous involvement.- - - - - - - - - - ranking = 1keywords = health (Clic here for more details about this article) |
10/14. Tuberculous skin ulcer following needle-prick injury in a health care professional.A case of cutaneous inoculation tuberculosis in a 25-year old health care professional is reported. The diagnosis was confirmed by histopathology and isolation of mycobacterium tuberculosis by BACTEC 460TB radiometric method. Rapid healing of the ulcer was noted in response to surgical debridement and specific anti-tuberculous therapy.- - - - - - - - - - ranking = 5keywords = health (Clic here for more details about this article) |
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