1/29. Tubulointerstitial nephritis and uveitis syndrome in two siblings.Two Japanese sisters with persistent uveitis showed significant increased levels of urinary beta-2 microglobulin. A percutaneous renal biopsy performed in the younger sister revealed tubulointerstitial nephritis (TIN) with helper/inducer T cell infiltrates. Also, abnormal 67-gallium accumulation in the kidneys, suggesting TIN, was observed in the other one at the same time. Although patients with the syndrome of tubulointerstitial nephritis and uveitis (TINU) have been reported to date, its occurrence in siblings has rarely been seen. Both of them shared same human leukocyte antigen (HLA) DR6, suggesting the potential association between HLA-DR6 and TINU.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |
2/29. Interstitial nephritis with concomitant uveitis. Report of two cases.In two female pediatric cases of uveitis with proteinuria and glycosuria, kidney biopsy demonstrated the presence of interstitial nephritis. Peripheral leukocytes responded positively in vitro in the leukocyte migration inhibition test with renal tubular antigen, thus suggesting the possibility that the patients' lymphocytes infiltrating into the renal parenchyma might be sensitized against the renal tubular antigen. Urinary beta2-microglobulin was also demonstrable and its levels correlated fairly well with the clinical course of uveitis in both cases.- - - - - - - - - - ranking = 2keywords = antigen (Clic here for more details about this article) |
3/29. Retinal S-antigen-reactive lymphocytes in a patient with uveitis associated with myelodysplastic syndromes.BACKGROUND: Although autoimmune humoral abnormalities have been reported in patients with myelodysplastic syndromes (MDS), abnormal organ-specific cellular autoimmunity has not been demonstrated. methods: Peripheral blood lymphocytes (PBLs) and serum were collected from a uveitis patient with MDS. Cellular immune response against retinal S-antigen (S-Ag) was assessed by proliferation assay, and humoral immune response to S-Ag was measured by enzyme-linked immunosorbant assay. RESULTS: PBLs from the patient exhibited vigorous proliferation against S-Ag, while humoral immune response against S-Ag was not detectable. PBLs from controls did not proliferate against S-Ag. CONCLUSION: These results provide new evidence that abnormal cellular immune responses against autoantigens may develop in MDS patients, thus leading to organ-specific autoimmune diseases such as uveitis, in addition to other systemic autoimmune disorders.- - - - - - - - - - ranking = 6keywords = antigen (Clic here for more details about this article) |
4/29. Juvenile ankylosing spondylitis with uveitis.A 17-year-old boy had suffered from right ankle arthralgia when he was 13 years old. He also had bilaterally congested conjunctivas and were erythematous around his right ankle joint. A soft tissue echo showed swelling of the right ankle joint. A Ga 67 scan revealed a focal elevated uptake in the right ankle, but a bone scan was negative. Reactive arthritis was suspected due to conjunctivitis, arthritis and a previous episode of watery diarrhea. An ophthalmologic examination showed no evidence of uveitis. Laboratory data were negative for rheumatoid factor, antinuclear antibody and anti-ds dna. Erythrocyte sedimentation rate (ESR) was 40 mm/hr and a histocompatibility test was positive for antigen B27. Based on the diagnosis of cellulitis and reactive arthritis, oxacillin and naproxen were given for 14 days. During follow-up at the OPD, bilateral arthralgia of the ankle joints was noted and a sonography showed bilateral edematous ankle joints. Juvenile ankylosing spondylitis (JAS) was suspected. Two years later, he had lower back pain and arthralgia of the knee joints with uveitis of the right eye. He was treated with naproxen and prednisolone. Because few JAS cases initially present as axial arthropathy or enthesopathy and uveitis is uncommon in children, we presented the case with a review of literature and conclusion that the possibility of JAS should be considered in young adolescent boys with arthritis of the lower limbs, enthesitis, a family history of related diseases and positive HLA-B27, as well as negative rheumatoid factor (RF) and anti-nuclear antibody (ANA) results.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |
5/29. Rational management of uveitis.Endogenous uveitis is an important cause of blindness in young adults. The need for a comprehensive search for an aetiological 'antigen' is stressed. A source of adjuvant, disturbance in host immunology and any associated syndromes are also sought. Treatment then involves elimination of 'antigen', suppression of host hypersensitivity and the enhanced vascular permeability, and improvement of host resistance. The value of antihistamine and antiserotonin drugs in successful treatment is emphasised.- - - - - - - - - - ranking = 2keywords = antigen (Clic here for more details about this article) |
6/29. Tubulo-interstitial nephritis and uveitis syndrome associated with mastitis: a case report.A new case of tubulo-interstitial nephritis and uveitis (TINU) syndrome in a 14-y-old girl is described. In this patient unilateral mastitis was an associated feature. The aetiology of this rare syndrome, the prognosis for which is usually good, is still unknown. The most common theory supports a cell-mediated immune response induced by infectious/antigenic stimuli. CONCLUSION: The presence of acute unilateral mastitis in this patient may represent an additional localization in TINU syndrome.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |
7/29. Cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma: a new cause of uveitis.Cytotoxic T Lymphocyte-associated antigen 4 (CTLA-4) is an important costimultory receptor expressed on activated T cells. CTLA-4 blockade using a monoclonal antibody (mAb) in conjunction with tumor vaccines has improved tumor responses in animal models and enhanced numerous models of T cell-associated autoimmune diseases. Two patients with stage IV metastatic melanoma vaccinated with the gp 100 melanocyte/melanoma differentiation antigen either before or during anti-CTLA-4 mAb therapy developed uveitis. This is the first report of autoimmune disease involving the eye in patients treated with anti-CTLA-4 mAb. This suggests that CTLA-4 is an important regulatory molecule for maintenance of tolerance to melanosomal antigens and prevention of uveitis.- - - - - - - - - - ranking = 7keywords = antigen (Clic here for more details about this article) |
8/29. serum sickness and uveitis.serum sickness is immune response to a foreign antigen, usually a heterologous protein. incidence rate is less than 0.5%. Antigens and responding antibodies form circulating immunocomplex that is characteristic for serum sickness. The condition occurs 7-15 days after exposure to the antigen, usually with clinical picture of glomerulonephritis. The immunocomplex circulates to other tissues where it sediments and causes inflammation, such as arteritis, neuritis, synovitis. The aim of this research is to present the break out of serum sickness in form of anterior uveitis due to azithromycin therapy administered by mouth. Identifying of anterior uveitis may help in early diagnostics and treatment of serum sickness.- - - - - - - - - - ranking = 2keywords = antigen (Clic here for more details about this article) |
9/29. Late developing lesions in birdshot retinochoroidopathy.Birdshot retinochoroidopathy is characterized by depigmented spots radiating from the optic disk in association with mild vitritis, retinal vasculitis, and involvement of the optic nerve head. In two patients, we traced the long-term course of uveitis with vitritis, retinal vasculitis, and papillitis that resulted in the typical cream-colored spots of birdshot retinochoroidopathy after seven and eight years, respectively, of follow-up. These observations suggest that in long-standing inflammation of the retinal vasculature and uveal tract, the HLA-A29 antigen should be assessed, because the development of typical lesions of birdshot retinochoroidopathy may be delayed in some patients.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |
10/29. panuveitis with positive serological tests for syphilis and lyme disease.The treponema pallidum hemagglutination test and the fluorescent treponemal antigen absorption test are commonly considered highly specific serologic tests for syphilis. We describe a patient with panuveitis and a positive serologic result for syphilis; however, in the absence of clinical findings, additional tests for lyme disease (borreliosis) were positive as well, although by Western blot test the diagnosis was tentative. The clinical appearance of the panuveitis was similar to that of syphilitic uveitis accompanied by pseudopigmentosa-like areas in the anterior retina. In the presence of uveitis with an otherwise unexplained positive serologic result for syphilis, the differential diagnosis of lyme disease should be considered.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |
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