1/14. Clinical and experimental evidence for persistent Yersinia infection in reactive arthritis.The findings of bacterial antigens in the joint and persistent triggering infection elsewhere in the body are thought to be important in the pathogenesis of reactive arthritis (ReA). We describe a patient with clinical and laboratory features consistent with this. The initial presentation with erythema nodosum and periarthritis due to infection with yersinia pseudotuberculosis IV was followed 13 months later by recurrent erythema nodosum with joint effusion. At that time, synovial fluid was shown to contain Yersinia antigens, and, surprisingly, Yersinia-specific 16S ribosomal rna (rRNA) sequences were also identified by reverse transcriptase-polymerase chain reaction and sequencing. Since there was no serologic evidence of reinfection, we postulate that a silent persistent Yersinia infection was reactivated, leading to dissemination of organisms to the joint, with consequent induction of ReA. Although the finding of synovial Yersinia antigens years after the original infection in ReA has previously been reported, the presence of Yersinia 16S rRNA indicates that viable organisms were also able to reach the joint.- - - - - - - - - - ranking = 1keywords = antigen (Clic here for more details about this article) |
2/14. HLA-DP restricted chlamydia trachomatis specific synovial fluid T cell clones in Chlamydia induced Reiter's disease.synovial fluid (SF) mononuclear cells from a patient with chlamydia trachomatis induced acute Reiter's disease were directly by limiting dilution in a representative protocol using phytohemagglutinin in the cloning medium. Out of 76 alpha beta-TCR CD4 T lymphocyte clones, 7 were shown to specifically recognize C. trachomatis in a proliferation assay. The antigen recognition of these clones was HLA-DP restricted. Unexpectedly, 2 HLA-DR restricted clones showed a proliferative response to yersinia enterocolitica O3, though the patient had no history of yersinia infection. The high frequency of SF derived T cells with specificity for species-specific chlamydial antigens and the limited diversity of HLA class II restriction of these clones may indicate an oligoclonal synovial T cell response to persistent intraarticular chlamydia.- - - - - - - - - - ranking = 0.66666666666667keywords = antigen (Clic here for more details about this article) |
3/14. Polyarteritis associated with yersinia enterocolitica infection.A patient developed polyarteritis, predominantly affecting the muscles, 10 days after a yersinia enterocolitica O:3 infection. Immunoperoxidase staining showed yersinia enterocolitica O:3 antigen in the subendothelial layer of the blood vessels. This suggests that vasculitis should be considered as a rare manifestation of yersinia enterocolitica infection.- - - - - - - - - - ranking = 0.33333333333333keywords = antigen (Clic here for more details about this article) |
4/14. Isolation of Yersinia-specific T cell clones from the synovial membrane and synovial fluid of a patient with reactive arthritis.synovial fluid (SF) mononuclear cells from patients with reactive arthritis (ReA) proliferate in vitro when challenged with ReA-associated bacteria, the maximal response being for the organism causing the triggering infection. We report the results of a study of the antigenic specificity of synovial T lymphocytes from an HLA-B27 positive ReA patient whose SF mononuclear cells responded preferentially to Yersinia antigens. This is the first report of the isolation of Yersinia-specific T cell clones from synovial membrane (obtained by closed-needle synovial biopsy). We present a detailed analysis of these clones, together with others obtained from the SF.- - - - - - - - - - ranking = 0.66666666666667keywords = antigen (Clic here for more details about this article) |
5/14. Late complications after a yersinia enterocolitica epidemic: a follow up study.Ninety four Finnish conscripts were affected by a yersinia enterocolitica epidemic in 1973. Thirteen years later 75 men completed a questionnaire about their present health. One half had no health problems, and the most common complaints in the other subjects were musculoskeletal disorders. Sixteen men wanted to be re-examined. In three cases a chronic connective tissue disease was diagnosed. Two men had ankylosing spondylitis. The most notable results of this study were (a) the fairly low number of late complications, (b) the close correlation between complications and the hla-b27 antigen, and (c) the correlation between raised yersinia antibody titres and the late complications. The nature of the primary causative agent may affect the development of late complications.- - - - - - - - - - ranking = 0.33333333333333keywords = antigen (Clic here for more details about this article) |
6/14. Haemolytic uraemic syndrome associated with yersinia enterocolitica infection.Haemolytic uraemic syndrome (HUS) associated with yersinia enterocolitica gastroenteritis is reported in a 6-year-old girl. Y. enterocolitica of biotype 03 was isolated from the patient's initial stool sample and was subsequently identified as serotype 03 based on the rising agglutinin titres. This paper shows that yersiniosis should be suspected as a possible cause of HUS, and investigations should include the measurement of serum agglutinin titres against antigen preparations of the genus Yersinia.- - - - - - - - - - ranking = 0.33333333333333keywords = antigen (Clic here for more details about this article) |
7/14. yersinia enterocolitica infection complicated by glomerulonephritis.A case of mild glomerulonephritis in a 24-year-old man with clinical and immunohistological findings associated with yersinia enterocolitica serotype 3 infection is described. The role of IgA in the pathogenesis of glomerulonephritis associated with mucosal infection is briefly discussed. Although attempts to demonstrate Y. enterocolitica 3 antigen in the biopsy specimen were unsuccessful, the glomerular deposits of immunoglobulins and complement suggest immune pathogenesis.- - - - - - - - - - ranking = 0.33333333333333keywords = antigen (Clic here for more details about this article) |
8/14. Postdiarrheal arthropathy of yersinia pseudotuberculosis.Two patients with acute gastroenteritis in whom polyarthritis subsequently developed were found to have positive serologic results for yersinia pseudotuberculosis. With resolution of the arthropathy the antibody titres decreased. While the patient without the histocompatibility antigen HLA-B27 had an acute, self-limited arthritis, the patient with this antigen had a more chronic arthritis. Serologic typing and stool culture for Y. pseudotuberculosis should be done in cases of postdysenteric arthritis.- - - - - - - - - - ranking = 0.66666666666667keywords = antigen (Clic here for more details about this article) |
9/14. adult Still's disease caused by yersinia enterocolitica infection.Clinical and biologic features of adult Still's disease developed in a patient who had high antibody titers against yersinia enterocolitica during his illness. Immunocomplexes containing antibodies against Yersinia antigens were isolated at the beginning of the disease. Yersinia was not isolated from blood or stool specimens probably because we observed the patient during the secondary phase of the disease.- - - - - - - - - - ranking = 0.33333333333333keywords = antigen (Clic here for more details about this article) |
10/14. Yersinia arthritis in the Midlands: clinical and immunological features in ten cases during 1980-1983.Ten cases of Yersinia arthritis, nine of whom were known to be B27 positive were seen in the Midlands between 1980 and 1983. Diagnostic difficulty arose in four cases owing to unusual form of presentation or course. Two of the cases studied during the acute phase showed a marked degree of lymphocyte transformation in the presence of Y. enterocolitica 0:3 in a dose-related form. This does not lend support to the concept of molecular mimicry between the bacterial antigen and the B27 gene product since this would be more likely to result in a diminished response.- - - - - - - - - - ranking = 0.33333333333333keywords = antigen (Clic here for more details about this article) |
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